In the realm of the avaricious samurai lord Daigo Kagemitsu, a crumbling land drives him to desperate measures. Abandoning Buddhism, he strikes a pact with twelve demons to gain the power to expand his domain, but the price is steep: his newborn firstborn is born missing limbs, a nose, eyes, ears, and skin, yet miraculously survives. Cast adrift in a river, the infant is later rescued by a healer who equips him with prosthetics and weapons to aid his survival. Though unable to see, hear, or feel touch, the boy is driven to hunt the demons that stole his body parts, regaining a piece of himself with each kill. After years of traveling alone, he encounters Dororo, another orphan who becomes his companion. Together, this unlikely pair battles to preserve their humanity in a harsh world teeming with demons.