In 1989, Joseph Joestar travels to Japan at the request of his daughter, Holly, to see his grandson, Joutarou Kuujou, who is troubled by inner conflict. Joutarou believes an evil spirit is controlling him, leading him to confine himself in a prison cell. Joseph explains that this "spirit" is actually a Stand, a physical manifestation of one's fighting spirit. Both Joseph and his companion, Mohammed Avdol, possess their own Stands and have mastered them.
During his visit, Joseph also learns alarming news: an ancient enemy of the Joestar family line has revived, awakening the Stand abilities of the Joestar bloodline. When Holly unexpectedly develops a Stand she cannot control, she becomes critically ill, requiring immediate action.
Armed with their Stand powers, Joseph, Avdol, and Joutarou set out on a global journey from Japan to Egypt to confront their foe. Along the way, they face many Stand-wielding opponents and form new alliances, all to save Holly and ultimately defeat their enemy.