In the grim and chaotic district known as Hole, where darkness and decay reign supreme and survival is a constant struggle, the powerful magic users hold absolute sway over a populace they regard as mere insects. The streets are rife with violence, and the hospitals overflow daily with the victims of murder, mutilation, and ruthless experimentation.
Amidst this desolate landscape, a few dare to challenge the magic users' dominion. One such figure is Caiman, a creature more akin to a reptile than a human, driven by a relentless pursuit of truth. Equipped with two trusted bayonets and blessed—or cursed—with immunity to magic, he stalks through Hole, haunted by his own appearance and plagued by nightmares. His sole allies against these malevolent sorcerers are his insatiable appetite and Nikaidou, the proprietor of the diner Hungry Bug, who stands steadfast beside him.
Dorohedoro unfolds in a nightmarishly designed world, blending dark humor and light-hearted moments with unflinching depictions of brutality and death. Through the tangled lives of Hole’s inhabitants, the series crafts a singular universe of eerie origin and bleak aesthetics, unsuitable for the faint of heart.