Lupin, Jigen, and Goemon board a mini-helicopter and fly toward the mysterious Drifting Island, drawn by rumors of a treasure hidden somewhere on it. As they explore the island, the trio comes up against the lethal Nanomachine, the island's security system. Their presence trips an alarm, bringing the Nanomachine to life. The key to unraveling the island's mystery lies in the small nation of Zufu, once a prosperous country now ruled by the ruthless, knife-collecting General Headhunter. Fujiko does her usual probing, hacking into General Headhunter's computer in hopes of uncovering vital information. Zenigata receives a video message from Lupin, in which Lupin declares his desire for the priceless treasure. Oleander, a fiery blond officer with hidden secrets of her own, steps in to aid Zenigata. Armed with the intel they've gathered, Lupin, Jigen, Goemon, and Fujiko return to Drifting Island—but this time, General Headhunter is following them.