In the distinctive setting of Class 77-B at Hope's Peak Academy, the students welcome Chisa Yukizome, a former pupil known as the Super High School-Level Housekeeper. With her lively personality and abilities, Chisa is committed to repairing the strained relationships among her diverse group of students, which includes a princess, a nurse, a yakuza member, and someone with extraordinary luck. Driven by a conviction in the power of hope, she works to guide them through their conflicts.
Meanwhile, Hajime Hinata, a Reserve Course student who doubts his own capabilities, forms a connection with Chiaki Nanami, the Super High School-Level Gamer. Through their interactions, Chiaki helps Hajime gain a new outlook on life. Unbeknownst to Hajime, however, the school authorities are devising a sinister scheme centered on him, one that could bring disaster to Hope's Peak Academy and beyond.
Zetsubou-hen captures the daily life at this prestigious institution while shadowy figures orchestrate malevolent plans in the background. As despair begins to eclipse hope, the masterminds behind the Biggest, Most Awful, Most Tragic Event in Human History set their plan into motion, signaling the beginning of the end.