For weeks, a mystical tiger has been haunting the orphanage where Atsushi Nakajima lives, yet only he seems oblivious to its presence. Suspected of causing the strange occurrences, the 18-year-old is suddenly expelled from the orphanage, left hungry, homeless, and wandering the city streets.
While starving on a riverbank, Atsushi saves a peculiar man named Osamu Dazai from drowning. An eccentric suicide enthusiast and supernatural detective, Dazai has been investigating the same tiger that has been tormenting the boy. Alongside Dazai's partner, Doppo Kunikida, they unravel the mystery, but its resolution leaves Atsushi in a difficult situation. As various odd events unfold, Atsushi is pressured into joining their agency of supernatural investigators, taking on unusual cases the police cannot handle, alongside his many enigmatic colleagues.