Nagisa Aoi transfers into St. Miator's Girls Academy, one of three elite all-female schools located on Astraea Hill. On her first day, she gets lost and runs into a stunning student whose spellbinding aura lands Nagisa in the infirmary.
When she regains consciousness, her roommate Tamao Suzumi greets her and explains the school's customs and social hierarchy. Tamao also tells Nagisa about the Etoile, a special student representative who leads all three academies. Curious, Nagisa discovers that the mesmerizing girl she encountered earlier, Shizuma Hanazono, holds this prestigious role. To her surprise, Shizuma takes a strong interest in Nagisa. As their bond grows, Nagisa becomes the talk of the campus, although she feels uneasy about certain elements of their dynamic.
"Strawberry Panic!" follows the day-to-day lives of Nagisa, Shizuma, and their friends from St. Miator's, St. Spica, and St. Lulim as they handle the intricacies of friendship and romance, uncover hidden truths, confront past emotions, and embrace new possibilities.