The invasion of the D2 species, unleashed by a black meteorite, has thrown the United States of America into turmoil. Because these creatures despise music, authorities banned all melodic performances to prevent further loss of life, a restriction still enforced in 2047. Humanity’s sole defense lies with the Musicarts, young women who personify classical compositions, and their partners, the Conductors. When a D2 assault turns Takt Asahina, a detached piano prodigy, into a Conductor, he forms a bond with Destiny, a Musicart. The attack also kills Cosette, the younger sister of Anna Schneider. To stabilize the pact between Takt and Destiny, the three embark on a perilous journey to Symphonica Headquarters in New York City. Takt yearns to play again, even though his music attracts the monsters he fears, while Destiny’s strict adherence to duty frequently causes complications. Confronted by D2-infested roads and various obstacles, the group must find a way to reach New York City alive.