In the realm of Hand Shakers, those selected by the Revelation of Babel are fated to undergo endless battles and trials. When they link hands with their fated partner, these Hand Shakers are transported to Ziggurat—a parallel dimension where time halts—and each duo vies to reach God, who bestows one wish upon the victors.
Tazuna Takatsuki, a high schooler talented at fixing things, gets caught up in this world after Professor Makihara asks him to repair an object. During that task, he meets Koyori Akutagawa, a girl confined to her bed who reminds him of his late sister, Musubu. Recalling Musubu’s final request that he never let go of her hand, Tazuna grasps Koyori’s hand, thus awakening his Hand Shaker powers. But Koyori’s existence is now bound to her role as a Hand Shaker, and if Tazuna ever releases her hand, she will die. To save Koyori, they must journey into Ziggurat together, utilize their unique abilities, overcome other Hand Shakers, and secure an audience with God to realize their wish.