In the typical lives of the frequently unlucky Bebop crew, another day means another bounty. However, their usual routine is disrupted when Faye, while chasing a barely valuable target on Mars, witnesses an oil tanker explode, causing mass hysteria. As casualties increase from a mysterious illness spread through the explosion's smoke, a massive three hundred million woolong reward is placed on the alleged culprit.
Driven by the need to save lives and the chance for financial relief, the Bebop team jumps into action. Spike, Jet, Faye, and Edward, along with Ein in tow, split up to follow various leads around Alba City. Their separate investigations reveal a cover-up involving a pharmaceutical corporation, uncovering a conspiracy that goes far beyond what these eclectic bounty hunters could have expected.