Based on the Argentine graphic novel series, this anime focuses on Cybersix, a super-soldier created through the cruel experiments of Dr. Von Reichter. A former Nazi, Von Reichter conducted horrific tests during WWII before escaping to South America, where he continued his research, leading to the creation of the "Cybers," including Cybersix herself. Because they developed independent thought, which was seen as a problem, Von Reichter eliminated all the Cybers to prevent possible rebellions.
In the present day, Cybersix, now living under the secret identity of "Adrian Seidelman," manages to avoid capture. She discovers that her existence depends on a unique substance created by Von Reichter, forcing her to hunt down the "Technos"—the new generation of super-soldiers—to ensure her survival. In doing so, she inadvertently takes on the role of a superhero, protecting the world from Von Reichter's creations and his evil plans.