In 1939, humanity teetered on the brink of annihilation. A mysterious alien race called the Neuroi, armed with catastrophic weaponry, launched an invasion of Earth, laying waste to nations and crushing human armies. To fight this seemingly unstoppable threat, the world’s powers united. They developed a new device, the Striker Unit, capable of countering Neuroi technology. Girls who wielded these units became known as Witches, humanity’s last line of defense. They began their battle against the Neuroi, harnessing their enhanced magical powers and wielding destructive weapons no ordinary human could handle.
By 1944, Yoshika Miyafuji, a young teenage girl, decides to join the 501st Joint Fighter Wing, also called the "Strike Witches." But with no formal training, can Miyafuji learn to work alongside her fellow Strike Witches? And if she can, will she be able to save humanity from the Neuroi onslaught?