In High School! Kimengumi, the members of the Funny-face Club reject ordinary high school life. The group includes Rei Ichidou, Gou Reietsu, Kiyoshi Shusse, Dai Monohoshi, and Jin Daima—each possessing distinct facial features and wildly eccentric personalities. Despite their differing temperaments, intellects, physical oddities, and behaviors, they are unmistakably strange. They interact with other colorful school factions such as the Pretty-boy Brigade, the Buckle-down Bunch, and the Rebel Crew, together with classmates like Yui Kawa and Chie Uru, as well as teachers who often get swept into the turmoil. The quintet throws themselves into an endless whirlwind of outrageous and chaotic adventures. This tale is filled with absurdity, randomness, and sheer madness, centering on five unforgettable misfits.