Scientists use a fossil from the Mythical Pokémon Mew to create Mewtwo, a Legendary Pokémon intended to be an immensely powerful weapon surpassing natural boundaries. After gaining self-awareness, Mewtwo becomes disillusioned with its origins and decides to seek revenge on its human creators. Satoshi, Pikachu, and their companions get caught up in the resulting chaos. With the future of the Pokémon world at stake, the group must confront Mewtwo's hostility as the creature struggles to find its own purpose.