In Izumo, the young shrine maiden Isanami barely escapes when a band of evil ninja set fire to her temple and slaughter everyone within. Fleeing into the forest, she encounters Saizou Kirigakure, a renegade ninja formerly of the Iga clan. The pair travel to Ueda Castle seeking aid from Yukimura Sanada. After learning of Isanami's concealed and dangerous power, Sanada pledges full support and begins assembling ten courageous warriors to safeguard her.
Set during the Warring States period, Brave 10 follows Isanami and Saizou's mission to recruit ten formidable fighters, each with unique abilities, to assist Yukimura. Their path leads them through war-torn lands, where they must repel those who seek to exploit Isanami's perilous strength for their own gain.
