In "Kamichama Karin," thirteen-year-old Karin Hanazono struggles through a tough life marked by the death of her parents and constant criticism from her aunt, who calls her stupid because of her bad grades. After losing her beloved cat, Shii-chan, Karin feels completely isolated. The only thing she has left from her parents is a special ring her mother gave her.
Her luck starts to improve when she meets Himeka Kuujou, another orphan, and Kazune Kuujou, Himeka's cousin who doesn't care much about girls. They are searching for a goddess. When they approach Karin, her mother's ring starts to glow, giving her sudden intelligence, speed, and the ability to make wishes come true. It becomes clear that Karin has the power to become the goddess they are looking for. This discovery draws the attention of people who want to take her powers for themselves.