Yuuko Konagai is a shy and socially awkward high school student who leads a quiet life, achieving average grades and having few classmates she can call friends. To escape the monotony of her daily routine, she returns home to find her talking cats, Maa, Shi, and Ro, waiting for her. These feline companions possess human-like forms and distinct personalities, giving Yuuko the affection and companionship she desires. Nyanko Days portrays the heartwarming moments between Yuuko and her charming cat friends as they share joyful experiences and strengthen their bonds over time.