The anime Attacker You! follows You Hazuki, a spirited and determined 13-year-old girl in junior high school. She moves from Osaka to Tokyo to live with her father Toshihiko, a cameraman just back from Peru, and attend school. Her mother left when You was very young, so she is not present. You's younger brother Sunny is deeply attached to her and follows her everywhere, including to school and volleyball matches. You is also intrigued by Kyushi Tajima, a pretty blonde woman she sees covering volleyball on TV, and wonders why her father becomes angry whenever You mentions her.
You is passionate about volleyball and dreams of joining Japan's national women's team for the 1988 Seoul Olympics. She joins her school's girls' volleyball team and quickly becomes a top player, though her coach—who is also her homeroom teacher—is harsh and physically slaps players when they fall short. She begins a tumultuous friendship with former school volleyball champion and former rival Nami Hayase (French name: "Peggy"), which escalates when the two join opposing professional teams. You also develops a crush on So Takiki, captain of the Hikawa boys' volleyball team (known as "Shiro," "Serge," or "Sergio" in various Western versions), and puts as much effort into winning his heart as into her game.