At the top of Tenikai General Hospital sits the unusual Department of Investigative Pathology, led by the eccentric Dr. Takao Ameku. This small team, made up of Takao and her only assistant, Yuu "Kotori" Takanashi, takes on difficult medical puzzles that leave other hospital units stumped. Driven by a love for mysteries, Takao frequently dives into baffling cases, much to the irritation of coworkers and local police. While her involvement creates headaches for both the hospital and those around it, there is no denying her remarkable diagnostic talents. Working together, Takao and the sometimes hesitant Takanashi can solve any medical riddle, no matter what kind it is.