Hustle Punch focuses on three homeless animals residing in a dilapidated vehicle atop a scrapyard: Punch, Touch, and Boom. Punch is a bear with a head as hard as stone, making him nearly indestructible. Boom, a weasel, is a skilled marksman who relies on a slingshot rather than firearms. Touch, a mouse, utilizes her tiny size to infiltrate restricted areas and evade detection by adversaries. Their primary antagonist is Gari-Gari, a wolf mad scientist determined to construct a mansion on the junkyard. He deviss various nefarious schemes to amass the funds required to purchase the land, ranging from manufacturing counterfeit 10 yen coins to stealing valuable artworks for resale. As an inventor, Gari-Gari creates gadgets to facilitate his crimes. Since acquiring the site would displace the trio, they repeatedly interfere with his plans. Gari-Gari employs two subordinates: Black, a cat gangster who frequently shoots at Punch and his friends, and Nyu, a strong but simple-minded pig.