Lupin, Goemon, and Jigen fly a small helicopter to the enigmatic "Drifting Island" in search of a treasure said to be hidden somewhere on it. As they explore the island, the trio confronts the deadly "Nanomachine," the island's security system. Their presence triggers an alarm, activating the Nanomachine. The key to unraveling the island's mystery lies in the tiny nation of Zufu. This once prosperous country is now governed by the cruel, knife-obsessed General Headhunter. Fujiko does her typical snooping and breaks into General Headhunter's computer, hoping to uncover vital data. Zenigata receives a video message from Lupin, in which Lupin declares his intent to obtain the priceless treasure. Oleander, a fiery blonde officer with a few secrets of her own, steps in to assist Zenigata. Armed with their newly acquired intelligence, Lupin, Goemon, Jigen, and Fujiko return to Drifting Island—but this time, they are tailed by General Headhunter.