When a demon-possessed boar attacks his Emishi village, young prince Ashitaka risks his life to defend his people. As the beast dies, it places a curse upon his arm, granting him supernatural strength while slowly draining his life force. Following the advice of the village elders, he journeys westward in search of a cure and arrives at Tatara, the Iron Town. There, he becomes caught in a bitter struggle: Lady Eboshi of Tatara, who relentlessly clears the forests, stands opposed to Princess San and the sacred spirits of the woods, enraged by humanity's destruction. As the forces of nature and civilization clash in a desperate fight for survival, Ashitaka seeks a way to bring peace between them, all while wrestling with the growing demon inside himself. Princess Mononoke tells the story of the bond between technology and nature, revealing the harmony attainable through mutual understanding.