In the busy streets of Tokyo, the City Hunter organization, known by the call sign XYZ, acts as a powerful force against crime, taking on any job without question. Its key member is Ryou Saeba, a sharpshooter armed with a Colt Python, who works alongside the tough and tomboyish Kaori Makimura. The pair confronts difficult cases and faces the many perils of their dangerous profession head-on. When not handling high-stakes assignments, Ryou spends his time pursuing attractive women, a habit often stopped by Kaori and her heavy hammer. Whether dealing with small-time thieves, arms dealers, or large crime syndicates, nothing can stop Ryou Saeba once he sets his sights on his next objective.