Hamtarou is a tiny, fluffy, and utterly charming hamster. After his owner, fifth-grader Hiroko Haruna, moves into a new home, Hamtarou encounters other hamsters and quickly forms friendships. Together, they form the Ham-Hams, a group of explorers eager to go anywhere. While their owners are away, the Ham-Hams embark on wild adventures throughout the city, ranging from theatrical performances to fantastical candy realms. At the same time, the humans navigate their own personal dramas. Hamtarou interacts with a diverse cast of characters, finds himself in and escapes from precarious situations, and assists Hiroko and her friends on multiple occasions. Despite all the excitement, he remains irresistibly adorable. It is time for Hamtarou!